Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy
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چکیده
منابع مشابه
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.
RATIONALE Cardiac myocyte-specific deletion of either glycogen synthase kinase (GSK)-3α and GSK-3β leads to cardiac protection after myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important consideration because of the fact that all GSK-3-targeted drugs, including the drugs already in clinical trial target both isoforms of GSK-3, ...
متن کاملResponse by Zhou et al to Letter Regarding Article, "Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy".
Response by Zhou et al to Letter Regarding Article, “Loss of Adult Cardiac Myocyte GSK3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy” In response: We thank Drs Karlstaedt and Taegtmeyer for their favorable comments on our recent report demonstrating mitotic catastrophe as a key mechanism of fatal dilated cardiomyopathy in glycogen synthase kinase 3 (GSK-3)–deficient he...
متن کاملLetter by Karlstaedt and Taegtmeyer Regarding Article, "Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy".
Letter by Karlstaedt and Taegtmeyer Regarding Article, “Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy” To The Editor: We have read with interest the article by Zhou et al. The authors demonstrated that in cardiomyocytes, conditional deletion of glycogen synthase kinase-3 (GSK-3) isoforms A and B leads to development of severe dilated ...
متن کاملTIMP-3 deficiency leads to dilated cardiomyopathy.
BACKGROUND Despite the mounting clinical burden of heart failure, the biomolecules that control myocardial tissue remodeling are poorly understood. TIMP-3 is an endogenous inhibitor of matrix metalloproteinases (MMPs) that has been found to be deficient in failing human myocardium. We hypothesized that TIMP-3 expression prevents maladaptive tissue remodeling in the heart, and accordingly, its d...
متن کاملLoss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.
RATIONALE Heart failure is a deadly and devastating disease that places immense costs on an aging society. To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function. OBJECTIVE microRNAs are important regulators of gene expression, and we sought to define the global contributions made by micr...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2016
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.308544